Pclo^em1Jgao
Endonuclease-mediated Allele Detail

Summary

• Symbol: Pclo^em1Jgao
• Name: piccolo (presynaptic cytomatrix protein); endonuclease-mediated mutation 1, Jiangang Gao
• MGI ID: MGI:7428501
• Gene: Pclo Location: Chr5:14564932-14913473 bp, + strand Genetic Position: Chr5, 6.27 cM, cytoband A2
• Alliance: Pclo^em1Jgao page

Mutation origin

• Strain of Origin: CBA/CaJ

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-cas9 mediated recombination using guide RNAs targeting exon 1 created a 4bp deletion resulting in expression of a 40 amino acid truncated protein. (J:322071)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pclo Mutation: 266 strains or lines available

References

• Original: J:322071 Li P, et al., Piccolo is essential for the maintenance of mouse retina but not cochlear hair cell function. Aging (Albany NY). 2021 Apr 21;13(8):11678-11695
• All: 1 reference(s)