Fxr1^em2Jil
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fxr1^em2Jil
• Name: FMR1 autosomal homolog 1; endonuclease-mediated mutation 2, Jinsong Li
• MGI ID: MGI:7428388
• Synonyms: Fxr1^L351P
• Gene: Fxr1 Location: Chr3:34074133-34124129 bp, + strand Genetic Position: Chr3, 16.41 cM, cytoband B
• Alliance: Fxr1^em2Jil page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the mutation responsible for the amino acid substitution of lysine with proline at position 351 (L351P). (J:332641)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fxr1 Mutation: 166 strains or lines available

References

• Original: J:332641 Kang JY, et al., LLPS of FXR1 drives spermiogenesis by activating translation of stored mRNAs. Science. 2022 Aug 12;377(6607):eabj6647
• All: 1 reference(s)