H19^em1Msb
Endonuclease-mediated Allele Detail

Summary

• Symbol: H19^em1Msb
• Name: H19, imprinted maternally expressed transcript; endonuclease-mediated mutation, Marisa S Bartolomei
• MGI ID: MGI:7427818
• Synonyms: delta H19, H19^{delta2.8kb-H19}
• Gene: H19 Location: Chr7:142129267-142131883 bp, - strand Genetic Position: Chr7, 87.97 cM
• Alliance: H19^em1Msb page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology generated a 2.8 kb deletion of the H19 transcription unit. (J:332215)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any H19 Mutation: 19 strains or lines available

References

• Original: J:332215 Chang S, et al., Dysregulated H19/Igf2 expression disrupts cardiac-placental axis during development of Silver-Russell syndrome-like mouse models. Elife. 2022 Nov 28;11
• All: 1 reference(s)