Dner^em1Jsag
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dner^em1Jsag
• Name: delta/notch-like EGF repeat containing; endonuclease-mediated mutation 1, Julien Sage
• MGI ID: MGI:7427702
• Gene: Dner Location: Chr1:84347560-84673942 bp, - strand Genetic Position: Chr1, 43.4 cM
• Alliance: Dner^em1Jsag page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-cas9 mediated recombination using guide RNAs targeting introns 1 and 4 created a deletion spanning exons 2 - 4. (J:324555)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dner Mutation: 47 strains or lines available

References

• Original: J:324555 Shue YT, et al., A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs. Nat Commun. 2022 May 16;13(1):2690
• All: 1 reference(s)