Gt(ROSA)26Sor^{tm1.1(CAG-Loxl2*)Lyxu}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1.1(CAG-Loxl2*)Lyxu}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Li-Yan Xu
• MGI ID: MGI:7427572
• Synonyms: L2delta13
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1.1(CAG-Loxl2*)Lyxu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:328844
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1.1(CAG-Loxl2*)Lyxu} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Loxl2 (MGI:2137913)	Gene lacks exon 13.

• Mutation details: The targeting construct inserted a CAG promoter, floxed STOP cassette, and the mouse gene lacking exon 13, which encodes part of the conserved catalytic domain. Cre-mediated recombination removed the STOP cassette. (J:328844)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

References

• Original: J:328844 Chen Y, et al., L2Delta13, a splicing isoform of lysyl oxidase-like 2, causes adipose tissue loss via the gut microbiota and lipid metabolism. iScience. 2022 Sep 16;25(9):104894
• All: 1 reference(s)