Trp73^em2Xch
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trp73^em2Xch
• Name: transformation related protein 73; endonuclease-mediated mutation 2, Xinbin Chen
• MGI ID: MGI:7427571
• Synonyms: E13^-
• Gene: Trp73 Location: Chr4:154140706-154224332 bp, - strand Genetic Position: Chr4, 83.79 cM
• Alliance: Trp73^em2Xch page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of exon 13 deleted 322 bp producing exon skipping of exon 13. This allele produces isoform beta but not isoform alpha. (J:332505)

Tumor Data

List all tumor models in MMHCdb carrying Trp73^em2Xch

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp73 Mutation: 47 strains or lines available

References

• Original: J:332505 Zhang J, et al., TP73 Isoform-specific disruption reveals a critical role of TAp73beta in growth suppression and inflammatory response. Cell Death Dis. 2023 Jan 11;14(1):14
• All: 1 reference(s)