Gt(ROSA)26Sor^{em2(CAG-Ocln*)Agon}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em2(CAG-Ocln*)Agon}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 2, Andreia Goncalves
• MGI ID: MGI:7427566
• Synonyms: S490AOCC
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em2(CAG-Ocln*)Agon} page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: CRISPR-targeting inserted into the locus a CAG promoter, floxed STOP cassette, mouse gene with the mutation encoding the amino acid substitution of serine with alanine at position 490 (S490A), IRES, and EGFP reporter gene. (J:328846)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

References

• Original: J:328846 Goncalves A, et al., Vascular Expression of Permeability-Resistant Occludin Mutant Preserves Visual Function in Diabetes. Diabetes. 2021 Jul;70(7):1549-1560
• All: 1 reference(s)