U2af1^em1Alfon
Endonuclease-mediated Allele Detail

Summary

• Symbol: U2af1^em1Alfon
• Name: U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1; endonuclease-mediated mutation 1, Alfonso Gutierrez-Adan
• MGI ID: MGI:7427508
• Synonyms: U2af1^mut
• Gene: U2af1 Location: Chr17:31866055-31877866 bp, - strand Genetic Position: Chr17, 17.02 cM
• Alliance: U2af1^em1Alfon page

Mutation origin

• Strain of Origin: (C57BL/6 x CBA)F1

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Intragenic deletion
• CRISPR-targeting of exon 6 deleted 5 bp resulting in a C-terminal truncation. (J:332548)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any U2af1 Mutation: 33 strains or lines available

References

• Original: J:332548 Martinez-Valiente C, et al., Aberrant Alternative Splicing in U2af1/Tet2 Double Mutant Mice Contributes to Major Hematological Phenotypes. Int J Mol Sci. 2021 Jun 28;22(13)
• All: 1 reference(s)