Garem1^em1.1Hkon
Endonuclease-mediated Allele Detail

Summary

• Symbol: Garem1^em1.1Hkon
• Name: GRB2 associated regulator of MAPK1 subtype 1; endonuclease-mediated mutation 1, Hiroaki Konishi
• MGI ID: MGI:7427461
• Gene: Garem1 Location: Chr18:21260399-21433196 bp, - strand Genetic Position: Chr18, 11.87 cM
• Alliance: Garem1^em1.1Hkon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:332460
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR-targeting floxed exon 4 and inserted an FRT-flanked neomysin resistance cassette. Cre-mediated recombination removed exon 4 and the selection cassette. (J:332460)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Garem1 Mutation: 47 strains or lines available

References

• Original: J:332460 Nishino T, et al., GAREM1 is involved in controlling body mass in mice and humans. Biochem Biophys Res Commun. 2022 Nov 5;628:91-97
• All: 1 reference(s)