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Cd55em1Cys
Endonuclease-mediated Allele Detail
Summary
Symbol: Cd55em1Cys
Name: CD55 molecule, decay accelerating factor for complement; endonuclease-mediated mutation 1, Jason G Cyster
MGI ID: MGI:7427391
Gene: Cd55  Location: Chr1:130366764-130390481 bp, - strand  Genetic Position: Chr1, 56.89 cM
Alliance: Cd55em1Cys page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCRISPR-cas9 mediated recombination using guide RNAs (CTGGCATTAGGAATGTCTGG and TCTGTCTTGAAAATGGCCAA) created a 139 bp deletion in exon 2 in the Cd55 gene. The identical sequence was also deleted in the Cd55b gene resulting in Cd55bem1Cysi allele. (J:324874)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd55 Mutation:  37 strains or lines available
References
Original:  J:324874 Liu D, et al., CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells. Science. 2022 Feb 11;375(6581):eabi5965
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory