Lcn2^tm1Hmhl
Targeted Allele Detail

Summary

• Symbol: Lcn2^tm1Hmhl
• Name: lipocalin 2; targeted mutation 1, Hsiu Hsieh-Li
• MGI ID: MGI:7427378
• Gene: Lcn2 Location: Chr2:32274649-32277751 bp, - strand Genetic Position: Chr2, 22.09 cM, cytoband A3
• Alliance: Lcn2^tm1Hmhl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:329491
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct replaced the coding region with a nuclear-localized lacZ gene and floxed neomycin resistance cassette. (J:329491)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lcn2 Mutation: 30 strains or lines available

References

• Original: J:329491 Wang E, et al., Overexpression of exogenous kidney-specific Ngal attenuates progressive cyst development and prolongs lifespan in a murine model of polycystic kidney disease. Kidney Int. 2017 Feb;91(2):412-422
• All: 1 reference(s)