Plpp6^tm1Bdl
Targeted Allele Detail

Summary

• Symbol: Plpp6^tm1Bdl
• Name: phospholipid phosphatase 6; targeted mutation 1, Bruce D Levy
• MGI ID: MGI:7427352
• Synonyms: Plpp6^-
• Gene: Plpp6 Location: Chr19:28941353-28944211 bp, + strand Genetic Position: Chr19, 23.61 cM, cytoband C2
• Alliance: Plpp6^tm1Bdl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:329994
• Parent Cell Line: PTL1 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• The targeting vector was designed to replace the entire coding region with a neomycin cassette. (J:329994)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Plpp6 Mutation: 13 strains or lines available

References

• Original: J:329994 Bruggemann TR, et al., Mouse phospholipid phosphatase 6 regulates dendritic cell cholesterol, macropinocytosis, and allergen sensitization. iScience. 2022 Oct 21;25(10):105185
• All: 1 reference(s)