Ltbp4^em1(IMPC)Tcp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ltbp4^em1(IMPC)Tcp
• Name: latent transforming growth factor beta binding protein 4; endonuclease-mediated mutation 1, The Centre for Phenogenomics
• MGI ID: MGI:7425804
• Gene: Ltbp4 Location: Chr7:27004561-27037117 bp, - strand Genetic Position: Chr7, 15.87 cM
• Alliance: Ltbp4^em1(IMPC)Tcp page
• IMPC: Ltbp4 gene page

Mutation origin

• Strain of Origin: C57BL/6NCrl
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Centre for Phenogenomics using Cas9 and guides with spacer sequences AACCCGCGGTGTTGTCGCAG and ATCTCTGGACCGGTCCAAGC that targeted exon(s) ENSMUSE00001395913.2 ENSMUSE00001396773.2 ENSMUSE00001398625.2 ENSMUSE00001401907.2 ENSMUSE00001403608.2 ENSMUSE00001766182.1 ENSMUSE00001766185.1 ENSMUSE00001766189.1 ENSMUSE00001766194.1 ENSMUSE00001766198.1 ENSMUSE00001766228.1. This resulted in deletion(s) of 2267 bp (location: Chr7:27024452-27026718; GRCm39). This description was generated automatically. Additional molecular information including FASTA sequence support for this allele can be found here: (IMPC Gene page) and viewed in a genome context here: (IMPC Genome Browser). (J:384794)

• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ltbp4 Mutation: 140 strains or lines available

References

• Original: J:265051 MGI and IMPC, MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). Database Release. 2018-2023
• All: 3 reference(s)