Plxnd1^em1Zho
Endonuclease-mediated Allele Detail

Summary

• Symbol: Plxnd1^em1Zho
• Name: plexin D1; endonuclease-mediated mutation 1, Zhou Zhou
• MGI ID: MGI:7425339
• Synonyms: Plxnd1^-
• Gene: Plxnd1 Location: Chr6:115931772-115971966 bp, - strand Genetic Position: Chr6, 53.72 cM
• Alliance: Plxnd1^em1Zho page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-cas9 mediated recombination using single specific guide RNA targeting exon 1 created a deletion that removed a genomic region including all of exon 1. (J:326461)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plxnd1 Mutation: 86 strains or lines available

References

• Original: J:326461 Zhou WZ, et al., Association of PLXND1 with a novel subtype of anomalous pulmonary venous return. Hum Mol Genet. 2022 May 4;31(9):1443-1452
• All: 1 reference(s)