Tlr7^em1Dvs
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tlr7^em1Dvs
• Name: toll-like receptor 7; endonuclease-mediated mutation 1, David V Serreze
• MGI ID: MGI:7425326
• Gene: Tlr7 Location: ChrX:166087925-166113554 bp, - strand Genetic Position: ChrX, 78.31 cM, cytoband F5
• Alliance: Tlr7^em1Dvs page

Mutation origin

• Strain of Origin: NOD/ShiLtJ

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting of the second coding exon deleted 2 bp. (J:329570)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tlr7 Mutation: 23 strains or lines available

References

• Original: J:329570 Debreceni IL, et al., Toll-Like Receptor 7 Is Required for Lacrimal Gland Autoimmunity and Type 1 Diabetes Development in Male Nonobese Diabetic Mice. Int J Mol Sci. 2020 Dec 13;21(24):9478
• All: 1 reference(s)