Crb3^tm1.1Vrls
Targeted Allele Detail

Summary

• Symbol: Crb3^tm1.1Vrls
• Name: crumbs family member 3; targeted mutation 1.1, Xaralabos Varelas
• MGI ID: MGI:7425294
• Synonyms: Crb3-loxP
• Gene: Crb3 Location: Chr17:57368583-57372920 bp, + strand Genetic Position: Chr17, 29.65 cM
• Alliance: Crb3^tm1.1Vrls page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:239794
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site and Rox flanked puro cassette were inserted upstream of exon 2 and an Frt flanked neo cassette and loxP site were inserted downstream of exon 5 via homologous recombination. Recombinase mediated recombination removed the puro and neo cassettes leaving exons 2 - 5 floxed. (J:239794)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crb3 Mutation: 10 strains or lines available

References

• Original: J:239794 Szymaniak AD, et al., Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap. Dev Cell. 2015 Aug 10;34(3):283-96
• All: 2 reference(s)