Gsdme^em2Broz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gsdme^em2Broz
• Name: gasdermin E; endonuclease-mediated mutation 2, Petr Broz
• MGI ID: MGI:7423800
• Gene: Gsdme Location: Chr6:50167013-50240837 bp, - strand Genetic Position: Chr6, 24.13 cM
• Alliance: Gsdme^em2Broz page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Undefined
• CRISPR-targeting exons 2 and 3 that result in a premature stop codon. (J:332350)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gsdme Mutation: 43 strains or lines available

References

• Original: J:332350 Chen KW, et al., RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate immune signaling. Proc Natl Acad Sci U S A. 2021 Jul 13;118(28):e2101189118
• All: 1 reference(s)