Agtpbp1^tm1.2Ksak
Targeted Allele Detail

Summary

• Symbol: Agtpbp1^tm1.2Ksak
• Name: ATP/GTP binding protein 1; targeted mutation 1.2, Kenji Sakimura
• MGI ID: MGI:7423634
• Synonyms: Nna1^deltaEx21,22
• Gene: Agtpbp1 Location: Chr13:59597348-59705184 bp, - strand
• Alliance: Agtpbp1^tm1.2Ksak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267307
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct inserted a loxP site upstream of exon 21 and an FRT-flanked neomycin resistance cassette with a 3' loxP site downstream of exon 22. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 21 and 22. (J:267307)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Agtpbp1 Mutation: 66 strains or lines available

References

• Original: J:267307 Zhou L, et al., Deletion of exons encoding carboxypeptidase domain of Nna1 results in Purkinje cell degeneration (pcd) phenotype. J Neurochem. 2018 Nov;147(4):557-572
• All: 1 reference(s)