Trp73^em1Xch
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trp73^em1Xch
• Name: transformation related protein 73; endonuclease-mediated mutation 1, Xinbin Chen
• MGI ID: MGI:7414276
• Synonyms: E12^-
• Gene: Trp73 Location: Chr4:154140706-154224332 bp, - strand Genetic Position: Chr4, 83.79 cM
• Alliance: Trp73^em1Xch page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting deleted exon 12. This mutation prevents expression of the p73alpha isoform in favor of the p73alpha1 isoform. (J:331403)

Tumor Data

List all tumor models in MMHCdb carrying Trp73^em1Xch

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp73 Mutation: 47 strains or lines available

References

• Original: J:331403 Laubach KN, et al., p73alpha1, a p73 C-terminal isoform, regulates tumor suppression and the inflammatory response via Notch1. Proc Natl Acad Sci U S A. 2022 May 31;119(22):e2123202119
• All: 1 reference(s)