Atl1^{em4(ATL1*)Lutzy}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Atl1^{em4(ATL1*)Lutzy}
• Name: atlastin GTPase 1; endonuclease-mediated mutation 1, Cathy Lutz
• MGI ID: MGI:7414015
• Synonyms: Atl1^em4Lutzy
• Gene: Atl1 Location: Chr12:69939879-70010859 bp, + strand Genetic Position: Chr12, 28.94 cM
• Alliance: Atl1^{em4(ATL1*)Lutzy} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Dominant negative, Humanized sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This CRISPR/cas9-mediated allele has a 919nt segment of human donor DNA containing Atl-1 Exon 12 with an M408T missense mutation inserted in place of 878nt mouse Atl-1 exon 13 and flanking introns, resulting in a dominant negative allele (J:94077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atl1 Mutation: 35 strains or lines available

References

• Original: J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015
• All: 1 reference(s)