Npffr2^em1Chejc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Npffr2^em1Chejc
• Name: neuropeptide FF receptor 2; endonuclease-mediated mutation 1, Jin-Chung Chen
• MGI ID: MGI:7413931
• Gene: Npffr2 Location: Chr5:89675288-89731599 bp, + strand Genetic Position: Chr5, 44.32 cM
• Alliance: Npffr2^em1Chejc page

Mutation origin

• Strain of Origin: C57BL/6JNarl

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-cas9 mediated recombination using guide RNAs created two deletions, one of 61 bp and one of 18 bp, in the transmembrane domain 2 of the protein. (J:324859)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npffr2 Mutation: 29 strains or lines available

References

• Original: J:324859 Lin YT, et al., Ablation of NPFFR2 in Mice Reduces Response to Single Prolonged Stress Model. Cells. 2020 Nov 14;9(11):2479
• All: 2 reference(s)