Slc26a5^tm1Xen
Targeted Allele Detail

Summary

• Symbol: Slc26a5^tm1Xen
• Name: solute carrier family 26, member 5; targeted mutation 1, Taconic Biosciences
• MGI ID: MGI:7413898
• Synonyms: prestin^Hsk
• Gene: Slc26a5 Location: Chr5:22015653-22070602 bp, - strand Genetic Position: Chr5, 9.97 cM, cytoband A3
• Alliance: Slc26a5^tm1Xen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:324886
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic region including exons 5 through 8 was replaced with a pgk-neo cassette via homologous recombination. Western blot analysis confirmed the absence of protein expression in cochlea from homozygous mice. (J:324886)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc26a5 Mutation: 58 strains or lines available

References

• Original: J:324886 Cheatham MA, et al., Evaluation of an independent prestin mouse model derived from the 129S1 strain. Audiol Neurootol. 2007;12(6):378-90
• All: 2 reference(s)