Col4a3^tm1Dlts
Targeted Allele Detail

Summary

• Symbol: Col4a3^tm1Dlts
• Name: collagen, type IV, alpha 3; targeted mutation 1, Constantinos Deltas
• MGI ID: MGI:7413121
• Synonyms: Col4a3-G1332E
• Gene: Col4a3 Location: Chr1:82564647-82699778 bp, + strand Genetic Position: Chr1, 42.32 cM
• Alliance: Col4a3^tm1Dlts page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:330820
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Single point mutation
• Mutation details: The targeting construct replaced exon 45 with an FRT-flanked neomycin resistance cassette and a modified exon 45 encoding the amino acid substitution glycine with glutamic acid at position 1332 (G1332E). (J:330820)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col4a3 Mutation: 63 strains or lines available

References

• Original: J:330820 Pieri M, et al., Evidence for activation of the unfolded protein response in collagen IV nephropathies. J Am Soc Nephrol. 2014 Feb;25(2):260-75
• All: 2 reference(s)