Erbb4^em2Corf
Endonuclease-mediated Allele Detail

Summary

• Symbol: Erbb4^em2Corf
• Name: erb-b2 receptor tyrosine kinase 4; endonuclease-mediated mutation 2, Gabriel Corfas
• MGI ID: MGI:7413112
• Synonyms: ErbB4-JMa^-
• Gene: Erbb4 Location: Chr1:68071345-69147218 bp, - strand Genetic Position: Chr1, 33.8 cM
• Alliance: Erbb4^em2Corf page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting of exon 16 introduced a single base pair deletion that produced a premature termination preventing the expression of the a isoform. (J:330826)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erbb4 Mutation: 87 strains or lines available

References

• Original: J:330826 Doherty R, et al., Identification of in vivo roles of ErbB4-JMa and its direct nuclear signaling using a novel isoform-specific knock out mouse. Sci Rep. 2022 Oct 14;12(1):17267
• All: 1 reference(s)