Erbb4^em1Corf
Endonuclease-mediated Allele Detail

Summary

• Symbol: Erbb4^em1Corf
• Name: erb-b2 receptor tyrosine kinase 4; endonuclease-mediated mutation 1, Gabriel Corfas
• MGI ID: MGI:7413111
• Synonyms: ErbB4-TUC
• Gene: Erbb4 Location: Chr1:68071345-69147218 bp, - strand Genetic Position: Chr1, 33.8 cM
• Alliance: Erbb4^em1Corf page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting of exon 16 introduced point mutations responsible for the amino acid substitutions of histidine with asparagine at position 641 (H641N) and serine with proline at position 642 (S642P). These mutations block TACE cleavage (J:330826)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Erbb4 Mutation: 87 strains or lines available

References

• Original: J:330826 Doherty R, et al., Identification of in vivo roles of ErbB4-JMa and its direct nuclear signaling using a novel isoform-specific knock out mouse. Sci Rep. 2022 Oct 14;12(1):17267
• All: 1 reference(s)