Hdac7^em1Iiis
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hdac7^em1Iiis
• Name: histone deacetylase 7; endonuclease-mediated mutation 1, Masashi Yanagisawa and Hiromasa Funato
• MGI ID: MGI:7412956
• Synonyms: HDAC7^ex20SA, HDAC7^SA
• Gene: Hdac7 Location: Chr15:97690545-97742383 bp, - strand Genetic Position: Chr15, 53.79 cM, cytoband F2
• Alliance: Hdac7^em1Iiis page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the point mutation A to C before exon 20 resulting in exon skipping and loss of functional protein. (J:332227)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac7 Mutation: 47 strains or lines available

References

• Original: J:332227 Kim SJ, et al., Kinase signalling in excitatory neurons regulates sleep quantity and depth. Nature. 2022;612(7940):512-518
• All: 1 reference(s)