Mybpc3^tm1Wali
Targeted Allele Detail

Summary

• Symbol: Mybpc3^tm1Wali
• Name: myosin binding protein C, cardiac; targeted mutation 1, Wolfgang A Linke
• MGI ID: MGI:7411395
• Synonyms: cMyBP-C^-, p/a-C1-
• Gene: Mybpc3 Location: Chr2:90948489-90966861 bp, + strand Genetic Position: Chr2, 50.44 cM, cytoband E1
• Alliance: Mybpc3^tm1Wali page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264726
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3-6 were deleted and replaced by a neomycin resistance gene. This produces a N-terminal deletion of the Ig domain C1 and the linker region between domains C0 and C1. The shortened deletion cardiac-specific variant (cMyBP-C) thus has a domain structure similar to that of skeletal variant (sMyBP-C). (J:264726)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mybpc3 Mutation: 41 strains or lines available

References

• Original: J:264726 Witt CC, et al., Hypercontractile properties of cardiac muscle fibers in a knock-in mouse model of cardiac myosin-binding protein-C. J Biol Chem. 2001 Feb 16;276(7):5353-9
• All: 2 reference(s)