F13a1^tm1.2Rjpe
Targeted Allele Detail

Summary

• Symbol: F13a1^tm1.2Rjpe
• Name: coagulation factor XIII, A1 subunit; targeted mutation 1.2, Richard J Pease
• MGI ID: MGI:7411394
• Synonyms: FXIII-A^-
• Gene: F13a1 Location: Chr13:37051152-37234220 bp, - strand Genetic Position: Chr13, 14.44 cM
• Alliance: F13a1^tm1.2Rjpe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264787
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Coding exon 7 (genomic exon 8) was flanked by loxP sites. An FRT-flanked neomycin phosphotransferase cassette was inserted in between exon 7 and the second loxP site and removed via flp-mediated recombination. Cre-mediated recombination deleted exon 7 in the germline. (J:264787)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any F13a1 Mutation: 48 strains or lines available

References

• Original: J:264787 Beckers CML, et al., Cre/lox Studies Identify Resident Macrophages as the Major Source of Circulating Coagulation Factor XIII-A. Arterioscler Thromb Vasc Biol. 2017 Aug;37(8):1494-1502
• All: 2 reference(s)