Gck^tm1.1Aztc
Targeted Allele Detail

Summary

• Symbol: Gck^tm1.1Aztc
• Name: glucokinase; targeted mutation 1.1, Astrazenica Transgenic Center
• MGI ID: MGI:7411377
• Synonyms: GK^-, gk^del
• Gene: Gck Location: Chr11:5850820-5900081 bp, - strand Genetic Position: Chr11, 3.88 cM
• Alliance: Gck^tm1.1Aztc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:291379
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 8 and a floxed neomycin phosphotransferase selectable marker cassette was inserted into intro 10. Cre-mediated recombination deleted exons 9-10 and the neomycin selection cassette. (J:291379)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gck Mutation: 64 strains or lines available

References

• Original: J:291379 Gorman T, et al., Effect of high-fat diet on glucose homeostasis and gene expression in glucokinase knockout mice. Diabetes Obes Metab. 2008 Sep;10(10):885-97
• All: 2 reference(s)