Fads2^em1Tyoko
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fads2^em1Tyoko
• Name: fatty acid desaturase 2; endonuclease-mediated mutation 1, Takehiko Yokomizo
• MGI ID: MGI:7411182
• Gene: Fads2 Location: Chr19:10040129-10078867 bp, - strand Genetic Position: Chr19, 6.36 cM, cytoband B
• Alliance: Fads2^em1Tyoko page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-cas9 mediated recombination using guide RNA (5'-CTCCGATGCCCACCTTCCGTTGG-3') created a 65 bp deletion downstream of the start codon. (J:329003)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fads2 Mutation: 22 strains or lines available

References

• Original: J:329003 Hayashi Y, et al., Ablation of fatty acid desaturase 2 (FADS2) exacerbates hepatic triacylglycerol and cholesterol accumulation in polyunsaturated fatty acid-depleted mice. FEBS Lett. 2021 Jul;595(14):1920-1932
• All: 1 reference(s)