Grb10^tm1.1Esze
Targeted Allele Detail

Summary

• Symbol: Grb10^tm1.1Esze
• Name: growth factor receptor bound protein 10; targeted mutation 1.1, Eric Szelenyi
• MGI ID: MGI:7410965
• Synonyms: Grb10^P2A-H2B-Venus
• Gene: Grb10 Location: Chr11:11880499-11987428 bp, - strand Genetic Position: Chr11, 7.15 cM
• Alliance: Grb10^tm1.1Esze page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (C57BL/6 x 129)F1

Mutation description

• Allele Type: Targeted (Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting vector is designed to replace the stop codon in exon 18 with a bicistronic reporter containing a P2A-H2B-Venus non-gene disruptive reporter cassette. The H2B-Venus nuclear reporter is a fusion protein consisting of the coding sequence of human histone 2B (human HIST1H2BB gene [histone 1 H2bb]) N-terminally fused to the yellow fluorescent protein Venus followed by an FRT-flanked neomycin selection cassette. Flp-mediated recombination removed the neo cassette. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grb10 Mutation: 56 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)