Marchf6^em1Hwac
Endonuclease-mediated Allele Detail

Summary

• Symbol: Marchf6^em1Hwac
• Name: membrane associated ring-CH-type finger 6; endonuclease-mediated mutation 1, Cheol-Sang Hwang
• MGI ID: MGI:7408582
• Gene: Marchf6 Location: Chr15:31456045-31531172 bp, - strand Genetic Position: Chr15, 12.95 cM
• Alliance: Marchf6^em1Hwac page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Undefined
• CRISPR-cas9 mediated recombination using guide RNAs targeting exon 2 created a null allele. (J:329236)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Marchf6 Mutation: 46 strains or lines available

References

• Original: J:329236 Nguyen KT, et al., The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis. Nat Cell Biol. 2022 Aug;24(8):1239-1251
• All: 1 reference(s)