Usp29^em2Gpt
Endonuclease-mediated Allele Detail

Summary

• Symbol: Usp29^em2Gpt
• Name: ubiquitin specific peptidase 29; endonuclease-mediated mutation 2, GemPharmatech Co., Ltd
• MGI ID: MGI:7408570
• Synonyms: Usp29^m
• Gene: Usp29 Location: Chr7:6733577-6970218 bp, + strand Genetic Position: Chr7, 4.04 cM
• Alliance: Usp29^em2Gpt page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR-targeting of exon 8 inserted 2 bp resulting in a frameshift and early translational termination. (J:310174)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Usp29 Mutation: 117 strains or lines available

References

• Original: J:310174 Zhang Q, et al., USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity. Cell Res. 2020 Oct;30(10):914-927
• All: 1 reference(s)