Casp2^tm1.1Ejac
Targeted Allele Detail

Summary

• Symbol: Casp2^tm1.1Ejac
• Name: caspase 2; targeted mutation 1.1, Etienne D Jacotot
• MGI ID: MGI:7408524
• Synonyms: Casp2^lox, Casp2^tm1.1Mka
• Gene: Casp2 Location: Chr6:42241942-42259442 bp, + strand Genetic Position: Chr6, 20.54 cM
• Alliance: Casp2^tm1.1Ejac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:330883
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct floxed exon 6 and Casp2S-specific exon. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:330883)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Casp2 Mutation: 25 strains or lines available

References

• Original: J:330883 Kim JY, et al., PIDDosome-SCAP crosstalk controls high-fructose-diet-dependent transition from simple steatosis to steatohepatitis. Cell Metab. 2022 Oct 4;34(10):1548-1560.e6
• All: 1 reference(s)