Slc40a1^tm2.1Nca
Targeted Allele Detail

Summary

• Symbol: Slc40a1^tm2.1Nca
• Name: solute carrier family 40 (iron-regulated transporter), member 1; targeted mutation 2.1, Nancy C Andrews
• MGI ID: MGI:7408486
• Synonyms: Fpn1 KO
• Gene: Slc40a1 Location: Chr1:45947228-45965683 bp, - strand Genetic Position: Chr1, 23.96 cM, cytoband B
• Alliance: Slc40a1^tm2.1Nca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:331974
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A floxed neo-cassette was inserted in intron 5 and a third loxP site was inserted in intron 7 via homologous recombination. Both exon 6 and the floxed neo cassette were removed by in vivo cre-mediated recombination. (J:129846)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc40a1 Mutation: 54 strains or lines available

References

• Original: J:331974 Cao C, et al., Loss of the placental iron exporter ferroportin 1 causes embryonic demise in late-gestation mouse pregnancy. Development. 2022 Dec 1;149(23):dev201160
• All: 2 reference(s)