Ptprj^em1Ael
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ptprj^em1Ael
• Name: protein tyrosine phosphatase receptor type J; endonuclease-mediated mutation 1, Ari Elson
• MGI ID: MGI:7408354
• Gene: Ptprj Location: Chr2:90260098-90410991 bp, - strand Genetic Position: Chr2, 50.19 cM, cytoband E1-2
• Alliance: Ptprj^em1Ael page

Mutation origin

• Strain of Origin: C57BL/6JOlaHsd

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-cas9 mediated recombination using guide RNAs targeting exons 4 and 14 created a deletion that removed most of the genomic region between these exons. This allele is in line 5. (J:329409)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptprj Mutation: 69 strains or lines available

References

• Original: J:329409 Shalev M, et al., PTPRJ promotes osteoclast maturation and activity by inhibiting Cbl-mediated ubiquitination of NFATc1 in late osteoclastogenesis. FEBS J. 2021 Aug;288(15):4702-4723
• All: 1 reference(s)