Trex1^em1Mpa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trex1^em1Mpa
• Name: three prime repair exonuclease 1; endonuclease-mediated mutation 1, Manolis Pasparakis
• MGI ID: MGI:7408326
• Gene: Trex1 Location: Chr9:108887000-108888791 bp, - strand Genetic Position: Chr9, 59.63 cM
• Alliance: Trex1^em1Mpa page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting deleted the coding exon. (J:331944)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trex1 Mutation: 29 strains or lines available

References

• Original: J:331944 Jiao H, et al., ADAR1 averts fatal type I interferon induction by ZBP1. Nature. 2022 Jul;607(7920):776-783
• All: 1 reference(s)