Adar^em1Mpa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Adar^em1Mpa
• Name: adenosine deaminase, RNA-specific; endonuclease-mediated mutation 1, Manolis Pasparakis
• MGI ID: MGI:7408323
• Synonyms: Adar1^mZalpha
• Gene: Adar Location: Chr3:89622329-89660753 bp, + strand Genetic Position: Chr3, 39.19 cM, cytoband F2
• Alliance: Adar^em1Mpa page

Mutation origin

• Strain of Origin: C57BL/6NRj

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting of exon 2 introduced the mutation for the amino acid substitution asparagine with alanine at position 175 and tyrosine for alanine at position 179 (N175A, Y179A). (J:331944)

Expression

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adar Mutation: 83 strains or lines available

References

• Original: J:331944 Jiao H, et al., ADAR1 averts fatal type I interferon induction by ZBP1. Nature. 2022 Jul;607(7920):776-783
• All: 1 reference(s)