Opn4^em2Yau
Endonuclease-mediated Allele Detail

Summary

• Symbol: Opn4^em2Yau
• Name: opsin 4 (melanopsin); endonuclease-mediated mutation 2, King-Wai Yu
• MGI ID: MGI:7408322
• Synonyms: Opn4^6A
• Gene: Opn4 Location: Chr14:34312575-34322099 bp, - strand Genetic Position: Chr14, 20.83 cM, cytoband B
• Alliance: Opn4^em2Yau page

Mutation origin

• Strain of Origin: (C57BL/6J x SJL/J)F1

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology changed the first six serine/threonine residues to alanine in the C-terminal tail (S388A, T389A, S391A, S392A, S394A, S395A) that are predicted GRK phosphorylation sites. Both the short and long isoforms are affected by this change. (J:319414)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Opn4 Mutation: 34 strains or lines available

References

• Original: J:319414 Sheng Y, et al., Molecular determinants of response kinetics of mouse M1 intrinsically-photosensitive retinal ganglion cells. Sci Rep. 2021 Dec 6;11(1):23424
• All: 1 reference(s)