Plcb4^em1Yau
Endonuclease-mediated Allele Detail

Summary

• Symbol: Plcb4^em1Yau
• Name: phospholipase C, beta 4; endonuclease-mediated mutation 1, King-Wai Yau
• MGI ID: MGI:7408321
• Synonyms: Plcb4^N256A
• Gene: Plcb4 Location: Chr2:135500931-135856513 bp, + strand Genetic Position: Chr2, 66.64 cM
• Alliance: Plcb4^em1Yau page

Mutation origin

• Strain of Origin: (C57BL/6J x SJL/J)F1

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology introduced an asparagine to alanine substitution at amino acid 256 (p.N256A). This mutation abolishes the enzymes GAP activity. (J:319414)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plcb4 Mutation: 132 strains or lines available

References

• Original: J:319414 Sheng Y, et al., Molecular determinants of response kinetics of mouse M1 intrinsically-photosensitive retinal ganglion cells. Sci Rep. 2021 Dec 6;11(1):23424
• All: 1 reference(s)