Zbp1^em2Mpa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zbp1^em2Mpa
• Name: Z-DNA binding protein 1; endonuclease-mediated mutation 2, Manolis Pasparakis
• MGI ID: MGI:7408306
• Synonyms: Zbp1^mZalpha2
• Gene: Zbp1 Location: Chr2:173048405-173060715 bp, - strand Genetic Position: Chr2, 95.83 cM, cytoband H3
• Alliance: Zbp1^em2Mpa page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting introduced the mutation responsible for the amino acid substitutions asparagine with aspartic acid at position 122 (N122D) and tyrosine with alanine at position 126 (Y126A). (J:289452)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zbp1 Mutation: 29 strains or lines available

References

• Original: J:289452 Jiao H, et al., Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation. Nature. 2020 Apr;580(7803):391-395
• All: 1 reference(s)