Zbp1^em1Mpa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zbp1^em1Mpa
• Name: Z-DNA binding protein 1; endonuclease-mediated mutation 1, Manolis Pasparakis
• MGI ID: MGI:7408293
• Gene: Zbp1 Location: Chr2:173048405-173060715 bp, - strand Genetic Position: Chr2, 95.83 cM, cytoband H3
• Alliance: Zbp1^em1Mpa page

Mutation origin

• Strain of Origin: C57BL/6NRj

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting deleted exons 2 and 3. (J:289452)

Expression

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zbp1 Mutation: 29 strains or lines available

References

• Original: J:289452 Jiao H, et al., Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation. Nature. 2020 Apr;580(7803):391-395
• All: 4 reference(s)