Rbm24^tm1.1Xixu
Targeted Allele Detail

Summary

• Symbol: Rbm24^tm1.1Xixu
• Name: RNA binding motif protein 24; targeted mutation 1.1, Xiuqin Xu
• MGI ID: MGI:7408183
• Synonyms: Rbm24^loxP
• Gene: Rbm24 Location: Chr13:46571910-46584571 bp, + strand Genetic Position: Chr13, 23.61 cM
• Alliance: Rbm24^tm1.1Xixu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:302917
• Parent Cell Line: B6/BLU (ES Cell)
• Strain of Origin: C57BL/6NTac-Tg(HBB-lacZ)ALey/Ley

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT-flanked neomycin cassette and second loxP site were inserted downstream of exon 3. The neomycin cassette was removed via flp-mediated recombination, leaving exon 2-3 floxed. (J:302917)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbm24 Mutation: 14 strains or lines available

References

• Original: J:302917 Liu J, et al., RNA binding protein 24 deletion disrupts global alternative splicing and causes dilated cardiomyopathy. Protein Cell. 2019 Jun;10(6):405-416
• All: 2 reference(s)