Mc4r^em1Toto
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mc4r^em1Toto
• Name: melanocortin 4 receptor; endonuclease-mediated mutation 1, Toshinobu Tokumoto
• MGI ID: MGI:7408128
• Synonyms: MC4R^G25S
• Gene: Mc4r Location: Chr18:66990776-66993558 bp, - strand Genetic Position: Chr18, 39.72 cM, cytoband E1
• Alliance: Mc4r^em1Toto page

Mutation origin

• Strain of Origin: LTXBJ/Sv

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: The TAKE method based on CRISPR/Cas9 technology generated a G to A change resulting in a glycine to serine substitution at amino acid 25 (p.G25S). (J:305716)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mc4r Mutation: 44 strains or lines available

References

• Original: J:305716 Naser AA, et al., MC4R mutant mice develop ovarian teratomas. Sci Rep. 2021 Feb 10;11(1):3483
• All: 2 reference(s)