Gt(ROSA)26Sor^{tm1.1(ADCY3)Zhwg}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1.1(ADCY3)Zhwg}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Zhenshan Wang
• MGI ID: MGI:7408121
• Synonyms: hAC3
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1.1(ADCY3)Zhwg} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:330926
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129 and C57BL/6N

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1.1(ADCY3)Zhwg} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ADCY3 (109)

  Adcy3

  (MGI:99675)

• Mutation details: The targeting construct inserted the human gene followed by an FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. (J:330926)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

References

• Original: J:330926 Yang D, et al., Ciliary Type III Adenylyl Cyclase in the VMH Is Crucial for High-Fat Diet-Induced Obesity Mediated by Autophagy. Adv Sci (Weinh). 2022 Jan;9(3):e2102568
• All: 1 reference(s)