Tfrc^{tm1(TFRC)Bdes}
Targeted Allele Detail

Summary

• Symbol: Tfrc^{tm1(TFRC)Bdes}
• Name: transferrin receptor; targeted mutation 1, Bart De Strooper
• MGI ID: MGI:7408102
• Synonyms: hAPI KI
• Gene: Tfrc Location: Chr16:32427738-32451612 bp, + strand Genetic Position: Chr16, 23.06 cM
• Alliance: Tfrc^{tm1(TFRC)Bdes} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:331899
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Tfrc^{tm1(TFRC)Bdes} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TFRC (7037)

  Tfrc	(MGI:98822)

• Mutation details: The targeting construct replaced the sequence encoding for amino acids 196-381 of the mouse sequence by the sequence encoding for amino acids 194-379 of the human gene, including the introns, encoding the apical domain (API). (J:331899)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tfrc Mutation: 63 strains or lines available

References

• Original: J:331899 Wouters Y, et al., VHHs as tools for therapeutic protein delivery to the central nervous system. Fluids Barriers CNS. 2022;19(1):79
• All: 1 reference(s)