Ticam1^tm1.2Mpa
Targeted Allele Detail

Summary

• Symbol: Ticam1^tm1.2Mpa
• Name: TIR domain containing adaptor molecule 1; targeted mutation 1.2, Manolis Pasparakis
• MGI ID: MGI:7407222
• Synonyms: Trif^mCherry
• Gene: Ticam1 Location: Chr17:56576462-56583767 bp, - strand Genetic Position: Chr17, 29.24 cM
• Alliance: Ticam1^tm1.2Mpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217312
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct a loxP site upstream of exon 2 and downstream of exon 2 an FRT-flanked neomycin resistance cassette with a 3' STOP sequence, loxP site, a splice acceptor, and an mCherry reporter gene. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 2 and the STOP sequence. (J:217312)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ticam1 Mutation: 54 strains or lines available

References

• Original: J:217312 Dannappel M, et al., RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature. 2014 Sep 4;513(7516):90-4
• All: 1 reference(s)