Igs46^em1Smun
Endonuclease-mediated Allele Detail

Summary

• Symbol: Igs46^em1Smun
• Name: intergenic sequence 46; endonuclease-mediated mutation 1, Stefan Mundlos
• MGI ID: MGI:7398618
• Gene: Igs46 Location: Chr11:110801622-110801623 bp Genetic Position: Chr11, Syntenic
• Alliance: Igs46^em1Smun page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235642
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxp site was inserted upstream of Kcnj16 at chr11:110801622-110801623 (GRCm39) using sgRNAs and an ssODN template with CRISPR/Cas9 technology. (J:235642)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igs46 Mutation: 0 strains or lines available

References

• Original: J:235642 Franke M, et al., Formation of new chromatin domains determines pathogenicity of genomic duplications. Nature. 2016 Oct 13;538(7624):265-269
• All: 1 reference(s)