Dp(11Kcnj16-Rr325)4Smun
Allele Detail

Summary

• Symbol: Dp(11Kcnj16-Rr325)4Smun
• Name: duplication, Chr 11, Stefan Mundlos 4
• MGI ID: MGI:7398594
• Synonyms: Dup-C
• Gene: Dp(11Kcnj16-Rr325)4Smun Location: unknown Genetic Position: Chr11, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235642
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Other (Conditional ready, Modified regulatory region)
• Mutations: Duplication, Insertion
• Dp(11Kcnj16-Rr325)4Smun involves 3 genes/genome features (Rr325, Kcnj16, Kcnj2) View all
• Mutation details: This duplication allele was created through cre-mediated inter-chromosomal recombination between loxP sites on two alleles: allele Igs46^em1Smun containing a single loxP site at chr11:110801622-110801623 (GRCm39), the other allele Igs45^{tm1(sb-SBlac)Smun} containing an SBlac cassette at chr11:112544204-112544205. It duplicates around half of the Kcnj topologically associated domain (TAD) and the Kcnj16 and Kcnj2 genes it contains, most of the Sox9 TAD (but not the gene itself), and insulator Rr325 between them. (J:235642)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dp(11Kcnj16-Rr325)4Smun Mutation: 0 strains or lines available

References

• Original: J:235642 Franke M, et al., Formation of new chromatin domains determines pathogenicity of genomic duplications. Nature. 2016 Oct 13;538(7624):265-269
• All: 1 reference(s)