Ovol2^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Ovol2^m1Btlr
• Name: ovo like zinc finger 2; mutation 1, Bruce Beutler
• MGI ID: MGI:7398547
• Synonyms: Ovol2^boh
• Gene: Ovol2 Location: Chr2:144147095-144174000 bp, - strand Genetic Position: Chr2, 70.99 cM, cytoband H1
• Alliance: Ovol2^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a G to A point mutation causing the amino acid substitution of cysteine to tyrosine at position 120 (C120Y) in isoform A (OVOL2-A) and position 87 (C87Y) in the shorter isoform B (OVOL2-B). (J:330954)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ovol2 Mutation: 23 strains or lines available

References

• Original: J:330954 Zhang Z, et al., Obesity caused by an OVOL2 mutation reveals dual roles of OVOL2 in promoting thermogenesis and limiting white adipogenesis. Cell Metab. 2022 Nov 1;34(11):1860-1874.e4
• All: 1 reference(s)